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Work by Hopkins team lights way to cancer 'milestone'
Posted on Thursday, September 04 @ 21:31:54 CDT by Raulken |
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By Frank D. Roylance | frank.roylance@baltsun.com Researchers cataloging the genetic codes of deadly human brain and pancreatic cancers say they have found several dozen defective genes that appear to work in concert to set off the tumor growth that...
 Cancer cellsThe most common form of brain cancer, known as glioblastoma multiforme, and pancreatic cancer carry a bleak prognosis. Only five percent of patients diagnosed with either disease are alive five years later.
Cancer researcher Paula Kiberstis is senior editor of the journal Science, which this week published two papers describing the discovery of several genetic abnormalities that are responsible for the two cancers.
Kiberstis says the findings may help answer two fundamental questions.
"After receiving a cancer diagnosis, a patient typically asks his or her physician two questions: Can you treat my cancer and what's my prognosis?," said Paula Kiberstis.
Kiberstis says the latest discoveries may ultimately improve the outlook for cancer patients.
In a comprehensive study looking for clues into the cause of glioblastoma and pancreatic cancer, two teams lead by researchers at the Howard Hughes Medical Institute and the Ludwig Center at The Johns Hopkins University in Maryland scoured 20,000 genes in 46 patients with pancreatic and brain cancer.
The researchers narrowed the culprits to about a dozen regulatory processes, or pathways, controlled by defective genes in about each tumor type.
In pancreatic cancer, the researchers linked the mutations to between 67 and 100 percent of pancreatic cancers.
Researchers were also surprised to discover a new mutation in a gene, called...
Click here to read the content (Source Voice of America)
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